Genetic and epidemiologic approaches to the search for gene-environment interaction: the case of osteoporosis.
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برآورد اثر متقابل ژن - محیط در سرطان پستان با مطالعات مورد - شاهد و فقط مورد
Background and Aim: Limitations of the traditional methods for assessing G*E interaction- including case-control studies- led to development of several non-traditional approaches. This study aims to assess the interaction between the genetic background (history of breast cancer in first degree relatives) and environmental influences (reproductive/menstrual factors) in patients with breast cance...
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Background: The traditional methods of studying the gene-environment interactions need a control group. However, the selection of an appropriate control group has been associated with problems. Therefore, new methods, such as case-only design, have been created to study such interactions. The objective of this study was to compare the case-only and case-control designs using data from patients ...
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Background and objectives: There is growing interest in assessing gene-environment interaction in the course of case-control studies. Difficulties related to the sampling of controls have led to the development of a range of non-traditional methods that do not require controls for estimating gene-environment interaction. One of these new modalities is the case-only approach, in which the asse...
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Background and Objectives: The role of gene-environment interaction in epidemiology has been widely considered. The traditional methods of studying the gene-environment interaction need appropriate control groups which their selection may be associated with some problems. Therefore, new methods have been created to study these interactions from which are the case-only designs. In this method,...
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عنوان ژورنال:
- American journal of epidemiology
دوره 147 1 شماره
صفحات -
تاریخ انتشار 1998